Common variants at 30 loci contribute to polygenic dyslipidemia
نویسندگان
چکیده
منابع مشابه
Common variants at ten genomic loci influence hemoglobin
Genotyping, imputation and quality control Study samples are described in Table 1. Study specific parameters and pre-imputation filters are specified in Table S1. Each study applied similar criteria for data calling. Prior to imputation, the criteria applied for exclusion of SNPs were: (i) minor allele frequency (MAF) <0.01, (ii) Hardy-Weinberg equilibrium P <10-4 or 10-6 and (iii) call-rate <0...
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OBJECTIVE Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA₁(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classifi...
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Christopher Newton-Cheh1–3,22, Mark Eijgelsheim4,22, Kenneth M Rice5,22, Paul I W de Bakker2,6,22, Xiaoyan Yin3,7, Karol Estrada8, Joshua C Bis9,10, Kristin Marciante9,10, Fernando Rivadeneira4,8, Peter A Noseworthy1, Nona Sotoodehnia9,11, Nicholas L Smith9,12,13, Jerome I Rotter14, Jan A Kors15, Jacqueline CM Witteman4,16, Albert Hofman4,16, Susan R Heckbert9,12,17, Christopher J O’Donnell3,18...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2008
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.291